1. TREG SYNDROME: "TREG cell abnormalities resulting in an excessive or impaired immunogenic response to an immunogen or auto-immunogen in a genetically predisposed individual resulting in inflammation, infection and/or cancer".
TREG syndrome is proposed as a disease model for diseases which previously did not have an obvious cause and were labelled idiopathic, essential or cryptogenic. 2. DENDRITIS: “Structural and functional changes in dendrites and dendritic spines secondary to an abnormal immunogenic response to an immunogen i.e. alcohol/drugs or auto-immunogen in a genetically predisposed individual”.
Dendritis is proposed as the underlying organic model for psychiatric disease incorporating the clinical, genetic, environmental, immunological and anatomical models of psychiatric disease. It is clear on Internet searches that:
1. TREGS are now being investigated in most diseases.
2. Dendritic spine structural and functional abnormalities are now being investigated in most psychiatric diseases.
This site is divided into the following:
1.Alcohol-drug syndrome - a model of dependency.
2. The regulatory T-cell (TREG) syndromes - a model of disease. 3.Autistic dendritis- a model of autism. 4. Dendritis- a model of psychiatric disease.
5. Hippocampitis - a model of memory impairment.
The models of an imbalance of TREGS and the resultant immuno-genetic response resulting in most diseases, and the abnormalities of dendritic spines resulting in psychiatric disease may be useful in the further understanding of disease.
These theories are works in progress and are not perfect. They are open to both constructive and destructive criticism. They may be useful in improving the understanding of disease in terms of changes in the immune system and in psychiatric disease in terms of changes in nerve structure.
The departure from the current chemical transmitter and receptor (lock and key) model of medicine particularly in psychiatric disease will be difficult to achieve in the short-term.
IMAGES
The image on the upper left is a microscopic view of a neuron`s dendritic spines.
